anti chip 2080 Search Results


anti chip antibody  (Cell Signaling Technology Inc)
95
Cell Signaling Technology Inc anti chip antibody
Anti Chip Antibody, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+chip+2080/CHIP+Rabbit+mAb/pmc09300310-50-18-27
Average 95 stars, based on 1 article reviews
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anti chip  (Santa Cruz Biotechnology)
95
Santa Cruz Biotechnology anti chip
Anti Chip, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+chip+2080/CHIP+Antibody/pmc08892744-49-30-19
Average 95 stars, based on 1 article reviews
anti chip - by Bioz Stars, 2026-09
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hrp-conjugate anti-ubiquitin  (Biomol GmbH)
90
Biomol GmbH hrp-conjugate anti-ubiquitin
Hrp Conjugate Anti Ubiquitin, supplied by Biomol GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+chip+2080/hrp+conjugated+anti+ub+antibodies+fk2/pmc02975794-76-5-8
Average 90 stars, based on 1 article reviews
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anti sting  (Cell Signaling Technology Inc)
98
Cell Signaling Technology Inc anti sting
Anti Sting, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+chip+2080/STING+Rabbit+mAb/pmc05931765-251-4-25
Average 98 stars, based on 1 article reviews
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anti tbk1  (Cell Signaling Technology Inc)
98
Cell Signaling Technology Inc anti tbk1
Anti Tbk1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+chip+2080/TBK1%2FNAK+Rabbit+mAb/pmc05931765-251-6-25
Average 98 stars, based on 1 article reviews
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anti c myc  (Santa Cruz Biotechnology)
96
Santa Cruz Biotechnology anti c myc
Anti C Myc, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+chip+2080/c-Myc+Antibody/pmc02975794-116-0-2
Average 96 stars, based on 1 article reviews
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anti brcc3  (Cell Signaling Technology Inc)
93
Cell Signaling Technology Inc anti brcc3
Anti Brcc3, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+chip+2080/BRCC36+Rabbit+mAb/pmc05931765-251-8-25
Average 93 stars, based on 1 article reviews
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anti ifnγ r1  (Santa Cruz Biotechnology)
93
Santa Cruz Biotechnology anti ifnγ r1
Anti Ifnγ R1, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+chip+2080/IFN-%CE%B3R%CE%B1+Antibody/bio_rxiv__2020__07__07__191650-234-6-7
Average 93 stars, based on 1 article reviews
anti ifnγ r1 - by Bioz Stars, 2026-09
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mdm2  (Cell Signaling Technology Inc)
96
Cell Signaling Technology Inc mdm2
Figure 4. VNPP433-3β triggers AR/AR-V7 degradation by promoting enhanced interaction of fAR with E3 ligases <t>MDM2</t> and CHIP. (A) CWR22Rv1 and (B) LNCaP cells were transfected with siRNA of MDM2 or CHIP (100 nM, Ambion) for 48 h and exposed to VNPP433-3β (10 µM) for 24 h and the lysates were immunoblotted for AR, MDM2, CHIP, and GAPDH. Scrambled siRNA served as control. CWR22Rv1 (C–F) and LNCaP (G–J) cells were hormone-starved for 48 h and treated with DMSO or VNPP433-3β for 4 h. Cell lysate containing 1 mg protein was subjected to immunoprecipitation and subsequent immunoblotting for AR, MDM2, HSP90, and CHIP.
Mdm2, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+chip+2080/MDM2+Rabbit+mAb/pm36078112-45-18-50
Average 96 stars, based on 1 article reviews
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hsp90  (Cell Signaling Technology Inc)
97
Cell Signaling Technology Inc hsp90
Figure 4. VNPP433-3β triggers AR/AR-V7 degradation by promoting enhanced interaction of fAR with E3 ligases MDM2 and CHIP. (A) CWR22Rv1 and (B) LNCaP cells were transfected with siRNA of MDM2 or CHIP (100 nM, Ambion) for 48 h and exposed to VNPP433-3β (10 µM) for 24 h and the lysates were immunoblotted for AR, MDM2, CHIP, and GAPDH. Scrambled siRNA served as control. CWR22Rv1 (C–F) and LNCaP (G–J) cells were hormone-starved for 48 h and treated with DMSO or VNPP433-3β for 4 h. Cell lysate containing 1 mg protein was subjected to immunoprecipitation and subsequent immunoblotting for AR, MDM2, <t>HSP90,</t> and CHIP.
Hsp90, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+chip+2080/HSP90+Rabbit+mAb/pm36078112-45-20-50
Average 97 stars, based on 1 article reviews
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anti mfn1  (Proteintech)
96
Proteintech anti mfn1
Figure 4. VNPP433-3β triggers AR/AR-V7 degradation by promoting enhanced interaction of fAR with E3 ligases MDM2 and CHIP. (A) CWR22Rv1 and (B) LNCaP cells were transfected with siRNA of MDM2 or CHIP (100 nM, Ambion) for 48 h and exposed to VNPP433-3β (10 µM) for 24 h and the lysates were immunoblotted for AR, MDM2, CHIP, and GAPDH. Scrambled siRNA served as control. CWR22Rv1 (C–F) and LNCaP (G–J) cells were hormone-starved for 48 h and treated with DMSO or VNPP433-3β for 4 h. Cell lysate containing 1 mg protein was subjected to immunoprecipitation and subsequent immunoblotting for AR, MDM2, <t>HSP90,</t> and CHIP.
Anti Mfn1, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+chip+2080/MFN1+Antibody/pmc07834979-192-26-28
Average 96 stars, based on 1 article reviews
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anti drp1  (Proteintech)
96
Proteintech anti drp1
Figure 4. VNPP433-3β triggers AR/AR-V7 degradation by promoting enhanced interaction of fAR with E3 ligases MDM2 and CHIP. (A) CWR22Rv1 and (B) LNCaP cells were transfected with siRNA of MDM2 or CHIP (100 nM, Ambion) for 48 h and exposed to VNPP433-3β (10 µM) for 24 h and the lysates were immunoblotted for AR, MDM2, CHIP, and GAPDH. Scrambled siRNA served as control. CWR22Rv1 (C–F) and LNCaP (G–J) cells were hormone-starved for 48 h and treated with DMSO or VNPP433-3β for 4 h. Cell lysate containing 1 mg protein was subjected to immunoprecipitation and subsequent immunoblotting for AR, MDM2, <t>HSP90,</t> and CHIP.
Anti Drp1, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+chip+2080/DRP1+(C-terminal)+Antibody/pmc07834979-192-23-25
Average 96 stars, based on 1 article reviews
anti drp1 - by Bioz Stars, 2026-09
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Image Search Results


Figure 4. VNPP433-3β triggers AR/AR-V7 degradation by promoting enhanced interaction of fAR with E3 ligases MDM2 and CHIP. (A) CWR22Rv1 and (B) LNCaP cells were transfected with siRNA of MDM2 or CHIP (100 nM, Ambion) for 48 h and exposed to VNPP433-3β (10 µM) for 24 h and the lysates were immunoblotted for AR, MDM2, CHIP, and GAPDH. Scrambled siRNA served as control. CWR22Rv1 (C–F) and LNCaP (G–J) cells were hormone-starved for 48 h and treated with DMSO or VNPP433-3β for 4 h. Cell lysate containing 1 mg protein was subjected to immunoprecipitation and subsequent immunoblotting for AR, MDM2, HSP90, and CHIP.

Journal: Cells

Article Title: Novel AR/AR-V7 and Mnk1/2 Degrader, VNPP433-3β: Molecular Mechanisms of Action and Efficacy in AR-Overexpressing Castration Resistant Prostate Cancer In Vitro and In Vivo Models.

doi: 10.3390/cells11172699

Figure Lengend Snippet: Figure 4. VNPP433-3β triggers AR/AR-V7 degradation by promoting enhanced interaction of fAR with E3 ligases MDM2 and CHIP. (A) CWR22Rv1 and (B) LNCaP cells were transfected with siRNA of MDM2 or CHIP (100 nM, Ambion) for 48 h and exposed to VNPP433-3β (10 µM) for 24 h and the lysates were immunoblotted for AR, MDM2, CHIP, and GAPDH. Scrambled siRNA served as control. CWR22Rv1 (C–F) and LNCaP (G–J) cells were hormone-starved for 48 h and treated with DMSO or VNPP433-3β for 4 h. Cell lysate containing 1 mg protein was subjected to immunoprecipitation and subsequent immunoblotting for AR, MDM2, HSP90, and CHIP.

Article Snippet: Primary antibodies against human AR (#5153), MNK1 (#2195), eIF4E (#2067), p-eIF4E (#9741), 4EBP1 (#9644), p-4EBP1 (#2855), CHIP (#2080), MDM2 (#86934), HSP90 (#4877), GAPDH (#5174), β-actin (#4970), BAX (#41162), BCL-2 (#15071), Capase9 (#9502), MNK2 (Sigma, M0696), secondary HRP-conjugated anti-rabbit (#7074), and HRP-conjugated anti-mouse (#7076) used in the study were procured from Cell Signaling Technology, USA unless otherwise mentioned.

Techniques: Transfection, Control, Immunoprecipitation, Western Blot

Figure 7. Graphical representation of the mechanism of action of VNPP433-3β in PCa inhibition. VNPP433-3β binds the AR, prevents its translocation into the nucleus, and redirects it to ubiquitina- tion by MDM2/CHIP and subsequent degradation by 26 S proteasome thereby affecting transcription of AR-responsive tumor genes and affecting PCa inhibition. Additionally, VNPP433-3β impedes phosphorylation of eIF4E by depleting MNK1/2 that in turn limits 5′-cap-dependent translation and blocks PCa progression.

Journal: Cells

Article Title: Novel AR/AR-V7 and Mnk1/2 Degrader, VNPP433-3β: Molecular Mechanisms of Action and Efficacy in AR-Overexpressing Castration Resistant Prostate Cancer In Vitro and In Vivo Models.

doi: 10.3390/cells11172699

Figure Lengend Snippet: Figure 7. Graphical representation of the mechanism of action of VNPP433-3β in PCa inhibition. VNPP433-3β binds the AR, prevents its translocation into the nucleus, and redirects it to ubiquitina- tion by MDM2/CHIP and subsequent degradation by 26 S proteasome thereby affecting transcription of AR-responsive tumor genes and affecting PCa inhibition. Additionally, VNPP433-3β impedes phosphorylation of eIF4E by depleting MNK1/2 that in turn limits 5′-cap-dependent translation and blocks PCa progression.

Article Snippet: Primary antibodies against human AR (#5153), MNK1 (#2195), eIF4E (#2067), p-eIF4E (#9741), 4EBP1 (#9644), p-4EBP1 (#2855), CHIP (#2080), MDM2 (#86934), HSP90 (#4877), GAPDH (#5174), β-actin (#4970), BAX (#41162), BCL-2 (#15071), Capase9 (#9502), MNK2 (Sigma, M0696), secondary HRP-conjugated anti-rabbit (#7074), and HRP-conjugated anti-mouse (#7076) used in the study were procured from Cell Signaling Technology, USA unless otherwise mentioned.

Techniques: Inhibition, Translocation Assay, Phospho-proteomics

Figure 4. VNPP433-3β triggers AR/AR-V7 degradation by promoting enhanced interaction of fAR with E3 ligases MDM2 and CHIP. (A) CWR22Rv1 and (B) LNCaP cells were transfected with siRNA of MDM2 or CHIP (100 nM, Ambion) for 48 h and exposed to VNPP433-3β (10 µM) for 24 h and the lysates were immunoblotted for AR, MDM2, CHIP, and GAPDH. Scrambled siRNA served as control. CWR22Rv1 (C–F) and LNCaP (G–J) cells were hormone-starved for 48 h and treated with DMSO or VNPP433-3β for 4 h. Cell lysate containing 1 mg protein was subjected to immunoprecipitation and subsequent immunoblotting for AR, MDM2, HSP90, and CHIP.

Journal: Cells

Article Title: Novel AR/AR-V7 and Mnk1/2 Degrader, VNPP433-3β: Molecular Mechanisms of Action and Efficacy in AR-Overexpressing Castration Resistant Prostate Cancer In Vitro and In Vivo Models.

doi: 10.3390/cells11172699

Figure Lengend Snippet: Figure 4. VNPP433-3β triggers AR/AR-V7 degradation by promoting enhanced interaction of fAR with E3 ligases MDM2 and CHIP. (A) CWR22Rv1 and (B) LNCaP cells were transfected with siRNA of MDM2 or CHIP (100 nM, Ambion) for 48 h and exposed to VNPP433-3β (10 µM) for 24 h and the lysates were immunoblotted for AR, MDM2, CHIP, and GAPDH. Scrambled siRNA served as control. CWR22Rv1 (C–F) and LNCaP (G–J) cells were hormone-starved for 48 h and treated with DMSO or VNPP433-3β for 4 h. Cell lysate containing 1 mg protein was subjected to immunoprecipitation and subsequent immunoblotting for AR, MDM2, HSP90, and CHIP.

Article Snippet: Primary antibodies against human AR (#5153), MNK1 (#2195), eIF4E (#2067), p-eIF4E (#9741), 4EBP1 (#9644), p-4EBP1 (#2855), CHIP (#2080), MDM2 (#86934), HSP90 (#4877), GAPDH (#5174), β-actin (#4970), BAX (#41162), BCL-2 (#15071), Capase9 (#9502), MNK2 (Sigma, M0696), secondary HRP-conjugated anti-rabbit (#7074), and HRP-conjugated anti-mouse (#7076) used in the study were procured from Cell Signaling Technology, USA unless otherwise mentioned.

Techniques: Transfection, Control, Immunoprecipitation, Western Blot